The temporary tissue that forms during the proliferative phase of wound healing, filling the wound bed with a matrix of new blood vessels (angiogenesis), fibroblasts, and extracellular matrix components. Healthy granulation tissue appears beefy red and granular—its color comes from the dense network of new capillaries.

Granulation tissue serves as the scaffold upon which epithelial cells migrate to close the wound surface. Its formation is one of the most commonly measured endpoints in preclinical wound healing studies, including many BPC-157 studies that report accelerated granulation tissue formation in rodent models. The relevance of faster granulation in rats to human wound healing is plausible but unconfirmed by controlled human trials.