The connection between how much of a compound you take and how strong the effect is — ideally a smooth curve, but sometimes surprisingly non-linear.A simple dose-response curve increases with dose until a plateau (Emax). Some peptides exhibit non-monotonic or hormetic dose-response curves, where low doses and high doses produce opposite effects — low-dose angiogenesis vs. high-dose anti-angiogenesis in some VEGF-related compounds, for example. This non-linearity is one reason extrapolating from animal dosing to human dosing is unreliable, and one reason community "more is better" assumptions about peptide dosing are sometimes specifically wrong.