A family of antimicrobial peptides stored in immune cells and released during infection—LL-37 is the only human cathelicidin.Cathelicidins are a family of antimicrobial peptides characterized by a conserved cathelin pro-domain and a variable C-terminal antimicrobial domain. Humans express a single cathelicidin gene (CAMP) producing hCAP-18, which is proteolytically cleaved to release the active peptide LL-37. LL-37 exhibits broad-spectrum antimicrobial activity, immunomodulatory functions, and wound healing promotion. Cathelicidins are stored in neutrophil specific granules and epithelial cells, released upon infection or injury.
