The primary receptor for nerve growth factor (NGF) — when activated, it tells neurons to survive, grow, and maintain their connections.TrkA is a receptor tyrosine kinase that autophosphorylates upon NGF binding, activating downstream PI3K/Akt (survival) and MAPK/ERK (growth and differentiation) signaling. Expressed on sensory neurons, sympathetic neurons, and corneal epithelial cells. Cenegermin (recombinant human NGF/Oxervate) acts via TrkA on corneal epithelial cells and trigeminal sensory nerve terminals to support corneal innervation and epithelial healing in neurotrophic keratitis.U↑ Top