A condition caused by too much growth hormone in adults—leading to enlarged hands, feet, and facial features.Acromegaly results from chronic GH hypersecretion, usually from a pituitary somatotroph adenoma. Excess GH and IGF-1 cause progressive somatic overgrowth, metabolic complications (insulin resistance, diabetes), cardiovascular disease, and increased mortality. First-line treatment after surgery is somatostatin analog therapy: octreotide LAR or lanreotide Autogel suppress GH secretion via SSTR2 activation on somatotroph tumor cells. Biochemical control (normalized IGF-1) is achieved in approximately 55–65% of patients on somatostatin analogs alone.