Inflammation of the middle layer of the eye (the uvea)—it can cause pain, redness, and vision loss if untreated.Uveitis is inflammation of the uveal tract (iris, ciliary body, choroid), classified by anatomical location: anterior (iritis), intermediate (pars planitis), posterior (choroiditis), and panuveitis. Etiologies include autoimmune disease, infection, and idiopathic causes. Treatment relies on corticosteroids and immunosuppressive agents. Melanocortin receptor agonists (PL-8177 targeting MC1R) represent a peptide-based anti-inflammatory approach under investigation for ocular inflammation, potentially offering targeted immunomodulation with fewer corticosteroid side effects.V↑ Top