How fast your body eliminates a drug from your bloodstream—measured in volume per time.Clearance (CL) represents the volume of plasma completely cleared of drug per unit time, typically expressed in mL/min or L/hr. For peptides, clearance occurs primarily through renal filtration, hepatic metabolism, and enzymatic degradation by tissue peptidases. High clearance necessitates frequent dosing or formulation modifications (PEGylation, fatty acid conjugation, albumin binding) to extend exposure. Clearance determines the maintenance dose required to achieve target steady-state concentrations.